Indian traditional system of medicine prescribes herbal remedies for treatment of diseases including diabetes. In recent years, plants are being successfully tried in variety of pathophysiological states. The present investigation, evaluated antidiabetic effect of hydro alcoholic extract of Hippophae rhamnoides L. seeds (HAHRS) in alloxan-induced diabetic rats. HAHRS (286 and 667 mg/kg) and glibenclamide (1 mg/kg) treatment was given to diabetic rats for 21 days and at the end of experimental period, serum glucose, cholesterol, HDL (High Density Lipoprotein), liver glycogen and glucose-6-phosphatase activities estimations were carried out. Statistical significance was assessed using one-way analysis of variance (ANOVA) followed by tukey comparison test. Results showed that because of alloxan treatment, serum level glucose, cholesterol and glucose-6-phosphatase activity increased, while HDL and liver glycogen decrease significantly which could be effectively and significantly blunted by HAHRS (667 mg/kg) and glibenclamide. This finding suggest that significant antidiabetic activity of HAHRS could be result of synergistic/potentiative anti-oxidant action of its medicinal phytoconstituents such as flavonoids, vitamin and carotenoids, since one of proposed mechanisms of diabetic effect of alloxan is through generation of free radicals and diverse array of active principles which are able to target multiple mechanisms involved in pathophysiology of diabetes.
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